Handbook of LC-MS Bioanalysis

Zusatztext

<p><b>Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules</b></p><p>The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results.</p><p>Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling.</p><p><i>Handbook of LC-MS Bioanalysis</i> features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines:</p><ul><li>Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring</li><li>The current understanding of regulations governing LC-MS bioanalysis</li><li>Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest</li><li>Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds</li></ul><p>With its focus on current bioanalytical practice,<i>Handbook of LC-MS Bioanalysis</i> enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.</p>

Autorenportrait

<p><b>WENKUI LI, PhD,</b> is Senior Fellow in the Department of Drug Metabolism& Pharmacokinetics at Novartis Institutes for BioMedical Research, where he focuses on regulated LC-MS/MS bioanalysis for the toxicokinetic and pharmacokinetic assessment of drug candidates. Dr. Li is a member of the editorial board of<i>Biomedical Chromatography</i>.</p><p><b>JIE ZHANG, PhD,</b> is Senior Fellow in the Department of Drug Metabolism& Pharmacokinetics at Novartis Institutes for BioMedical Research, where he focuses on regulated LC-MS bioanalysis for the toxicokinetic and pharmacokinetic assessment of drug candidates. In addition, Dr. Zhang evaluates and implements novel technologies and processes in regulated LC-MS bioanalysis.</p><p><b>FRANCIS L. S. TSE, PhD,</b> is Vice President of Drug Metabolism& Bioanalytics at Novartis Institutes for BioMedical Research, overseeing the unit's strategy and operations in North America and Asia. Dr. Tse is a Fellow of the American Association of Pharmaceutical Scientists, APhA Academy of Pharmaceutical Research and Science, and American College of Clinical Pharmacology.</p>

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