Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

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InhaltsangabeI. Ionic Determinants of Electrical Activity.- 1. Calcium current and excitation-contraction coupling in heart.- 2. Role of cytosolic calcium in the normal and ischemic heart: potential new insights from the second generation indicator, Indo-1.- 3. Repetitive activity: origin of the Na+ load and its physiologic effects.- 4. Ionic changes associated with acute ischemia.- 5. Mechanisms of reperfusion arrhythmias.- II. Metabolic Factors in Ischemia.- 6. Ischemia and Na+/K+ pump function.- 7. Amphipathic lipid metabolites and arrhythmogenesis: a perspective.- 8. Free radicals and myocardial injury during ischemia and reperfusion: a short-lived phenomenon?.- 9. Thyroid hormones and cardiac function.- III. Neural and Hormonal Factors.- 10. Receptor mechanisms in ischemia and infarction.- 11. Sympathetic-parasympathetic interactions in the normal heart.- 12. Central nervous system modulation of cardiac rhythm.- 13. Influence of ischemia and infarction on cardiac vagal and sympathetic innervation.- IV. Arrhythmogenic Nechanisms.- 14. On the problem of anisotropic propagation in ventricular muscle.- 15. Anisotropic reentry: A model of arrhythmias that may necessitate a new approach to antiarrhythmic drug development.- 16. Arrhythmias in the early ischemic period.- 17. Arrhythmias and the healed myocardial infarction.- V. Strategies for Prediction, Prevention and Therapy.- 18. Clinical significance and limitations of ventricular late potentials.- 19. Pacing to predict mechanism: transient entrainment and reentry.- 20. The value of programmed electrical stimulation in triggered activity-induced arrhythmias.- 21. Pharmacologic mechanisms in the treatment of arrhythmias due to ischemia and infarction.- 22. Cardiac innervation and sudden death: new strategies for prevention.

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