Synthesis Of Novel Anti-inflammatory Agents With Good Gastric Profiles

Zusatztext

Inflammation is a worldwide distributing disease, annoying a lot of people so it is necessary to discover drugs that are capable of eliminating this disease. This dissertation concerned with synthesis of novel indole derivatives as indomethacin analogues. As we Know indomethacin is one of the most potent anti-inflammatory agents but with high gastric toxicity due to its non selective inhibition of both COX isozymes. So, we decided to synthesize these compounds which characterized by high potency and great safety gastric profiles.

Autorenportrait

Ahmed Hefny is an ass.lecturer at Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef university. He graduated in 2012 and completed his master thesis in 2017.He has a passion in chemical synthesis of organic compounds, modification of novel compounds from existing ones and all issues related to chemistry.

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