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Statistical Human Genetics

Methods and Protocols, Methods in Molecular Biology 850
Humana Press
ISBN/EAN: 9781617795541
Umbreit-Nr.: 1282917

Sprache: Englisch
Umfang: xi, 564 S.
Format in cm:
Einband: gebundenes Buch

Erschienen am 04.02.2012
Auflage: 1/2012
€ 160,49
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  • Zusatztext
    • Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans. In Statistical Human Genetics: Methods and Protocols expert researchers in the field describe statistical methods and computer programs in the detail necessary to make them more easily accessible to the beginner analyzing data. Written in the highly successful Methods in Molecular Biology series format, with examples of running the programs and interpreting the program outputs, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results from human genetic data collected in the laboratory.  Thorough and as much as possible intuitive, Statistical Human Genetics: Methods and Protocols aids scientists in understanding the computer programs and analytical procedures they need to use.
  • Kurztext
    • Demonstrates methods in a wide variety of computer programsProvides step-by-step detail essential for reproducible resultsContains key notes and implementation advice from the experts
  • Autorenportrait
    • Inhaltsangabe1. Genetic terminology       2. Identification of genotype errors3. Detecting pedigree relationship errors        4. Identifying cryptic relationships       5. Estimating allele frequencies6. Testing departure from Hardy-Weinberg proportions        7. Estimating disequilibrium  coefficients                                            8. Detecting familial aggregation         9. Estimating heritability from twin studies     10. Estimating heritability from nuclear family and pedigree data      11. Correcting for ascertainment12. Segregation analysis using the unified model       13. Design considerations for genetic linkage and association studies           14. Model-based linkage analysis of a quantitative trait                                                        15. Model-based linkage analysis of a binary trait      16. Model-free linkage analysis of a quantitative trait                                           17. Model-free linkage analysis of a binary trait          18. Single marker association analysis for unrelated samples                      19. Single marker family-based association analysis conditional on parental information                                                            20. Single marker family-based association analysis not conditional on parental information            21. Allowing for population stratification in association analysis         22. Haplotype inference     23. Multi-SNP haplotype analysis methods for association analysis                                                24. Detecting rare variants  25. The analysis of ethnic mixtures     26. Identifying gene interaction networks        27. Structural equation modeling        28. Genotype calling for the Affymetrix  platform                                           29. Genotype calling for the Illumina platform                                                        30. Comparison of requirements and capabilities of major multipurpose software packages