Detailansicht
Novel Co-Processed Superdisintegrants for Sublingual Tablets
ISBN/EAN: 9783659696855
Umbreit-Nr.: 8223885
Sprache:
Englisch
Umfang: 112 S.
Format in cm: 0.7 x 22 x 15
Einband:
kartoniertes Buch
Erschienen am 22.05.2015
Auflage: 1/2015
- Zusatztext
- Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 & 2:1) by co-processing and physical mixing. The result showed that the formulation containing co-processed superdisintegrant in the ratio of 1:2 (CP2) showed faster disintegration, wetting, dispersion and maximum drug release. The disintegration time of optimized formulation (CP2) was upto 7 sec. The % in vitro drug release of Enalapril Maleate was 100.52 % in 3 min. Ex vivo permeation of CP2 was found to be 92.26±0.96% in 6 min. Thus, from the present work it reveals that the co-processed superdisintegrants formulation are superior to physical mixture formulation. Sublingual tablets of Enalapril Maleate gives faster drug release because of presence of superdisintegrants and may improve bioavailability of Enalapril Maleate.
- Autorenportrait
- Ankita Patel recieved her B.Pharm from Gujarat University and M.Pharm from Gujarat Technological University. She has published and presented research papers at national and international level. She is working as an assistant professor at Maliba Pharmacy college, UTU, since 2012. Her current area of research is drug delivery through nanotechnology.