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The Neuropathology of Huntington's Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
eBook - Advances in Anatomy, Embryology and Cell Biology
Heinsen, Helmut/Korf, Horst-Werner/Rüb, Udo et al
ISBN/EAN: 9783319192857
Umbreit-Nr.: 9276454
Sprache:
Englisch
Umfang: 0 S., 8.21 MB
Format in cm:
Einband:
Keine Angabe
Erschienen am 29.09.2015
Auflage: 1/2015
E-Book
Format: PDF
DRM: Digitales Wasserzeichen
- Zusatztext
- This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.