Detailansicht
Metastasis of Colorectal Cancer
Cancer Metastasis - Biology and Treatment 14
ISBN/EAN: 9789400732933
Umbreit-Nr.: 4008464
Sprache:
Englisch
Umfang: xvi, 416 S.
Format in cm:
Einband:
kartoniertes Buch
Erschienen am 13.10.2012
Auflage: 1/2013
- Zusatztext
- InhaltsangabeIntroduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis 1.1.1 The progression model 1.1.2 The transient compartment model 1.1.3 The early oncogenesis model 1.1.4 The fusion model 1.1.5 The gene transfer models 1.1.6 The genetic predisposition model 1.2 Metastatic steps 1.2.1 Development of the primary colorectal cancer 1.2.1.1 Initiation of the primary neoplasm 1.2.1.2 Influence of stromal cells 1.2.1.3 Influence of the extracellular matrix 1.2.1.4 EpithelialMesenchymal transition 1.2.1.5 Angiogenesis and lymphangiogenesis 1.2.2 Intravasation 1.2.3 Circulation of cancer cells 1.2.4 Extravasation 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread 2.1.1 Circulatory spread 2.1.1.1 Lymphatic spread 2.1.1.2 Hematogenous spread 2.1.2 Local spread 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread 2.2.1 Liver 2.2.1.1 Steps in liver invasion 2.2.1.2 Development of liver failure 2.2.2 Lungs 2.2.3 Peritoneum 2.2.4 Bone and bone marrow 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread 2.3.1 Tumour factors 2.3.1.1 Tissue Factor 2.3.1.2 EGFR 2.3.2 Host factors 2.3.2.1 Immunity 2.3.2.2 Diet, exercise and liver disease 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability 3.3.1 Overview 3.3.2 Chromosome Instability 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways 3.4.1 Wingless/Wnt Signalling Pathway 3.4.1.1 APC 3.4.1.2 BCatenin (CTNNB1) 3.4.2 KRAS, BRAF and RASRAFMAPK Signalling Pathway 3.4.2.1 KRAS 3.4.2.2 BRAF 3.4.3 p53 (TP53) 3.4.4 The Phosphatidylinositol 3kinase (PI3K) Pathway 3.4.4.1 PIK3CA 3.4.4.2 PTEN 3.4.5 TGFB Signalling Pathways 3.4.5.1 TGFBR2 3.4.5.2 The SMAD Family of Genes 3.4.5.3 TGFB Superfamily Receptors: ACVR2 and BMPR1A 3.5 GenomeWide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to co
- Kurztext
- InhaltsangabeIntroduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis 1.1.1 The progression model 1.1.2 The transient compartment model 1.1.3 The early oncogenesis model 1.1.4 The fusion model 1.1.5 The gene transfer models 1.1.6 The genetic predisposition model 1.2 Metastatic steps 1.2.1 Development of the primary colorectal cancer 1.2.1.1 Initiation of the primary neoplasm 1.2.1.2 Influence of stromal cells 1.2.1.3 Influence of the extracellular matrix 1.2.1.4 EpithelialMesenchymal transition 1.2.1.5 Angiogenesis and lymphangiogenesis 1.2.2 Intravasation 1.2.3 Circulation of cancer cells 1.2.4 Extravasation 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread 2.1.1 Circulatory spread 2.1.1.1 Lymphatic spread 2.1.1.2 Hematogenous spread 2.1.2 Local spread 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread 2.2.1 Liver 2.2.1.1 Steps in liver invasion 2.2.1.2 Development of liver failure 2.2.2 Lungs 2.2.3 Peritoneum 2.2.4 Bone and bone marrow 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread 2.3.1 Tumour factors 2.3.1.1 Tissue Factor 2.3.1.2 EGFR 2.3.2 Host factors 2.3.2.1 Immunity 2.3.2.2 Diet, exercise and liver disease 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability 3.3.1 Overview 3.3.2 Chromosome Instability 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways 3.4.1 Wingless/Wnt Signalling Pathway 3.4.1.1 APC 3.4.1.2 BCatenin (CTNNB1) 3.4.2 KRAS, BRAF and RASRAFMAPK Signalling Pathway 3.4.2.1 KRAS 3.4.2.2 BRAF 3.4.3 p53 (TP53) 3.4.4 The Phosphatidylinositol 3kinase (PI3K) Pathway 3.4.4.1 PIK3CA 3.4.4.2 PTEN 3.4.5 TGFB Signalling Pathways 3.4.5.1 TGFBR2 3.4.5.2 The SMAD Family of Genes 3.4.5.3 TGFB Superfamily Receptors: ACVR2 and BMPR1A 3.5 GenomeWide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to colorectal cancer metastasis 4.8 Epigenetic biomarkers and therapies References 5. Cancerinitiating Cells in Colorectal Cancer; A. Kreso, L. Gibson, C.A. O'Brien 5.1 Introduction 5.2 The cell surface phenotype of colon cancer- initiating cells 5.3 COLON CANCER-INITIATING CELLs and chemoresistance 5.4 The role of CANCER-INITIATING CELLs in metastases 5.5 CANCERINITIATING CELLs as biomarkers 5.6 CANCERINITIATING CELLs and clinical trials 5.7 Cell of origin and COLON CANCER-INITIATING CELLs 5.8 Controversies in the cancer stem cell field 5.9 Conclusions References 6. Epithelial-Mesenchymal Transition in Colorectal Cancer; O. Schmalhofer, S. Brabletz, T. Brabletz
- Autorenportrait
- InhaltsangabeIntroduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis 1.1.1 The progression model 1.1.2 The transient compartment model 1.1.3 The early oncogenesis model 1.1.4 The fusion model 1.1.5 The gene transfer models 1.1.6 The genetic predisposition model 1.2 Metastatic steps 1.2.1 Development of the primary colorectal cancer 1.2.1.1 Initiation of the primary neoplasm 1.2.1.2 Influence of stromal cells 1.2.1.3 Influence of the extracellular matrix 1.2.1.4 EpithelialMesenchymal transition 1.2.1.5 Angiogenesis and lymphangiogenesis 1.2.2 Intravasation 1.2.3 Circulation of cancer cells 1.2.4 Extravasation 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread 2.1.1 Circulatory spread 2.1.1.1 Lymphatic spread 2.1.1.2 Hematogenous spread 2.1.2 Local spread 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread 2.2.1 Liver 2.2.1.1 Steps in liver invasion 2.2.1.2 Development of liver failure 2.2.2 Lungs 2.2.3 Peritoneum 2.2.4 Bone and bone marrow 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread 2.3.1 Tumour factors 2.3.1.1 Tissue Factor 2.3.1.2 EGFR 2.3.2 Host factors 2.3.2.1 Immunity 2.3.2.2 Diet, exercise and liver disease 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability 3.3.1 Overview 3.3.2 Chromosome Instability 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways 3.4.1 Wingless/Wnt Signalling Pathway 3.4.1.1 APC 3.4.1.2 BCatenin (CTNNB1) 3.4.2 KRAS, BRAF and RASRAFMAPK Signalling Pathway 3.4.2.1 KRAS 3.4.2.2 BRAF 3.4.3 p53 (TP53) 3.4.4 The Phosphatidylinositol 3kinase (PI3K) Pathway 3.4.4.1 PIK3CA 3.4.4.2 PTEN 3.4.5 TGFB Signalling Pathways 3.4.5.1 TGFBR2 3.4.5.2 The SMAD Family of Genes 3.4.5.3 TGFB Superfamily Receptors: ACVR2 and BMPR1A 3.5 GenomeWide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to co