Detailansicht
Environmental Epigenomics in Health and Disease
Epigenetics and Human Health 0, Epigenetics and Human Health
ISBN/EAN: 9783642233791
Umbreit-Nr.: 1615330
Sprache:
Englisch
Umfang: xv, 302 S.
Format in cm:
Einband:
gebundenes Buch
Erschienen am 29.05.2013
Auflage: 1/2013
- Zusatztext
- InhaltsangabeIntroduction - Frederick L. Tyson.- Fetal Origins of Adult Disease Susceptibility.- 1) Randy L. Jirtle - Epigenetics: How Genes and Environment Interact.- 2) Peter D. Gluckman, Felicia M. Low, and Mark A. Hanson - Developmental Epigenomics and Metabolic Disease.- 3) Susan K. Murphy, and Cathrine Hoyo - Sculpting Our Future: Environmental Nudging of the Imprintome.- Epigenetics and Environmental Exposures.- 1) Christopher Faulk, and Dana C. Dolinoy - Complex Phenotypes: Epigenetic Manifestation of Environmental Exposure.- 2) Olga Kovalchuk - Epigenetic Effects of Ionizing Radiation.- 3) Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya-Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos, Vilius Stribinskis, and Ted Kalbfleisch - The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury.- Epigenetics, Gene Regulation, and Stem Cells.- 1) John M. Denu - Environmental Impact on Epigenetic Histone Language.- 2) Aleksandra B. Adomas, and Paul A. Wade - Chromatin Structure and Gene Expression - Function Follows Form.- 3) R. David Hawkins, and Bing Ren - Epigenetics of Pluripotency.- Epigenetic Transgenerational Inheritance.- 1) Luan Wang, Xiangyi Lu, and Douglas M. Ruden - Transgenerational Epigenetic Inheritance in Drosophila.- 2) Michael K. Skinner - Environmental Epigenetics and Epigenetic Transgenerational Inheritance.- 3) Marcus E. Pembrey, Lars O. Bygren, and Jean Golding - The Nature of Human Transgenerational Responses.- Epigenetic Programming of the Brain.- 1) Eric B. Keverne - Epigenetics and Maternal Brain Evolution.- 2) Moshe Szyf - Social Environment and DNA Methylation: A Mechanism for Linking Nurture and Nature.- 3) Anthony P. Auger, and Catherine J. Auger - Sex Differences in Epigenetic Programming of Brain Differentiation: Implications for Mental Health and Disease.- Epigenetics and Neurological Disorders.- 1) Jon F. Wilkins - Phenotypic Plasticity, Pleiotropy, and the Growth-First Theory of Imprinting.- 2) Christopher Badcock - The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis.- 3) Janine M. LaSalle; Roxanne O. Vallero, and Michelle M. Mitchell - Epigenetics at the Interface of Genetics and Environmental Factors in Autism.- 4) John S. Satterlee - Epigenomic and Non-Coding RNA Regulation in Addictive Processes.- 5) Hsien-Sung Huang, Benjamin D. Philpot, and Yong-hui Jiang - Epigenetic Therapies in Neurological Diseases.-Epigenetics, Nutrition, and Chronic Diseases.- 1) Janos Zempleni, Dandan Liu, and Jing Xue - Nutrition, Histone Epigenetic Marks, and Disease.- 2) Ian C. Wood - Chromatin Switching and Gene Dynamics Associated with Type 2 Diabetes.- 3) Caroline L. Relton, George Davey Smith, and Susan E. Ozanne - Developmental Epigenetic Programming in Diabetes and Obesity.- Epigenetics and Cancer.- 1) F. Javier Carmona, and Manel Esteller - Human Cancer Epigenetics.- 2) Cheryl L. Walker - Developmental Reprogramming by Environmental Estrogens: How Early Life Exposures Affect Cancer Risk in Adulthood.- Epigenetics and the Law.- 1) Mark A. Rothstein - Legal and Ethical Implications of Epigenetics.- Subject Index
- Kurztext
- Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.
- Autorenportrait
- InhaltsangabePreface Frederick L. Tyson.- Fetal Origins of Adult Disease Susceptibility.- 1) Randy L. Jirtle - Epigenetics: How Genes and Environment Interact.- 2) Peter D. Gluckman, Felicia M. Low, and Mark A. Hanson - Developmental Epigenomics and Metabolic Disease.- 3) Susan K. Murphy, and Cathrine Hoyo - Sculpting Our Future: Environmental Nudging of the Imprintome.- Epigenetics and Environmental Exposures.- 1) Christopher Faulk, and Dana C. Dolinoy - Complex Phenotypes: Epigenetic Manifestation of Environmental Exposure.- 2) Olga Kovalchuk - Epigenetic Effects of Ionizing Radiation.- 3) Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya-Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos, Vilius Stribinskis, and Ted Kalbfleisch - The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury.- Epigenetics, Gene Regulation, and Stem Cells.- 1) John M. Denu - Environmental Impact on Epigenetic Histone Language.- 2) Aleksandra B. Adomas, and Paul A. Wade - Chromatin Structure and Gene Expression - Function Follows Form.- 3) R. David Hawkins, and Bing Ren - Epigenetics of Pluripotency.- Epigenetic Transgenerational Inheritance.- 1) Luan Wang, Xiangyi Lu, and Douglas M. Ruden - Transgenerational Epigenetic Inheritance in Drosophila.- 2) Michael K. Skinner - Environmental Epigenetics and Epigenetic Transgenerational Inheritance.- 3) Marcus E. Pembrey, Lars O. Bygren, and Jean Golding - The Nature of Human Transgenerational Responses.-Subject Index
- Schlagzeile
- InhaltsangabePreface Frederick L. Tyson.- Fetal Origins of Adult Disease Susceptibility.- 1) Randy L. Jirtle - Epigenetics: How Genes and Environment Interact.- 2) Peter D. Gluckman, Felicia M. Low, and Mark A. Hanson - Developmental Epigenomics and Metabolic Disease.- 3) Susan K. Murphy, and Cathrine Hoyo - Sculpting Our Future: Environmental Nudging of the Imprintome.- Epigenetics and Environmental Exposures.- 1) Christopher Faulk, and Dana C. Dolinoy - Complex Phenotypes: Epigenetic Manifestation of Environmental Exposure.- 2) Olga Kovalchuk - Epigenetic Effects of Ionizing Radiation.- 3) Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya-Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos, Vilius Stribinskis, and Ted Kalbfleisch - The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury.- Epigenetics, Gene Regulation, and Stem Cells.- 1) John M. Denu - Environmental Impact on Epigenetic Histone Language.- 2) Aleksandra B. Adomas, and Paul A. Wade - Chromatin Structure and Gene Expression - Function Follows Form.- 3) R. David Hawkins, and Bing Ren - Epigenetics of Pluripotency.- Epigenetic Transgenerational Inheritance.- 1) Luan Wang, Xiangyi Lu, and Douglas M. Ruden - Transgenerational Epigenetic Inheritance in Drosophila.- 2) Michael K. Skinner - Environmental Epigenetics and Epigenetic Transgenerational Inheritance.- 3) Marcus E. Pembrey, Lars O. Bygren, and Jean Golding - The Nature of Human Transgenerational Responses.-Subject Index